HPMC Empty Capsule

HPMC Empty Capsule

HPMC stands for hydroxypropyl methylcellulose or hypromellose for short. HPMC is the material from which most supplement capsules are made.

Description

Company Profile

 

 

Prime Source Group is a top supplier in pharmaceutical industry and chemical industry.
Empty Capsules, Aluminum Foil, PVC Sheet and Plastic Bottles are our main pharmaceutical related products. They are manufactured in three professional factories with rich experience and GMP workshops.

 

Why choose us?

100% customer satisfaction

Prime Source is in charge of marketing above pharmaceutical related products with superior service and immediate feedback. Customer satisfaction is our ultimate mission.

Best service

Supply quality products and services with consistent quality. Offer highest credibility, best product quality and stability and soonest response to our customers.

 

Rich experience

With 20 years of R&D experience, we focus on the two industries of pharmaceutical packaging and food packaging, and maintain strategic cooperative relations with many brand enterprises in the industry.

Global shipping

Our products support global shipping and the logistics system is complete, so our customers are all over the world.

 

 

 

HPMC Vegetable Capsule Shell

HPMC Vegetable Capsule Shell

HPMC is a mature capsule form, which has successfully replaced gelatin in the pharmaceutical industry for many years and has been widely used. Our HPMC Vegetable Capsule Shell is made of this material, which is transparent, smooth, low fragile and high-quality empty capsule, which is considered safe for normal human consumption. It is the perfect choice for various capsule fillers, without any chemical additives, fats and preservatives, and is suitable for drug diversity.

HPMC Vegetarian Capsule

HPMC Vegetarian Capsule

This HPMC Vegetarian Capsule is a high-quality capsule for filling powdered herbs, vitamins, essential oils or other powder supplements. It is made of HPMC (hydroxypropyl methyl cellulose), its main components are plant cell wall and polysaccharide, which has stable molecular structure and good film-forming performance. In addition, it does not contain other additives, fat or protein, so it is also suitable for people who cannot eat gelatin for any religious, cultural or dietary reasons.

HPMC Capsule Shell

HPMC Capsule Shell

This HPMC Capsule Shell contains gellan gum, which is an empty capsule, allowing you to make your own health care products, and is very suitable for filling powder or herbal medicine. At the same time, it will be packed in a resealable bag to keep away from light, air and moisture, so as to ensure that your powder or supplement remains fresh and ready for use. In addition, it is produced in the GMP workshop with strict specifications and standards, which can achieve high filling rate, high stability and high consistency, and bring you convenient and stable use effect.

Hpmc Hard Capsules

Hpmc Hard Capsules

This Hpmc Hard Capsules is a capsule without any formula, has a hard appearance and is made of high-quality HPMC material. It has a wide range of applications, and can be used to contain various essential oils, powder and particles. When the drug has an unpleasant smell or taste, you can also use it to cover it up. In addition, it is made by skilled and stable production technology to ensure perfect appearance, and its surface is free of bubbles, spots and wrinkles.

Hpmc Capsule

Hpmc Capsule

This Hpmc Capsule is very suitable for filling all kinds of essential oils, powders and granules, and is used as a powder supplement for home packaging. It can mix and package various powders to produce specific mixture and efficacy, and save you a lot of costs to reduce economic expenditure. At the same time, it has a low water content and is very suitable for humidity sensitive, hygroscopic and liquid formulations, which will effectively extend the shelf life of the drug through the sealed shell state.

Clear HPMC Capsules

Clear HPMC Capsules

The Clear HPMC Capsules will allow you to no longer swallow animal-derived gelatin capsules, you can use it to load various powders, granules and oils for other products you need to ingest. It is made of high-quality HPMC material, being a capsule derived from plant ingredients, without any sunscreen and any pigment. Therefore, even if it is used for a long time, it will benefit the human body. In addition, its transparent appearance design can clearly show the ingredients in the capsule, which gives us a reliable feeling.

Colored HPMC Capsules

Colored HPMC Capsules

Our Colored HPMC Capsules are empty capsules, they are used for household and medical purposes, which can be used to contain various kinds of powder, granules and essential oil products. It is convenient to use. They are manufactured and packaged in accordance with the latest GMP certification standards, and are made of 100% medical-grade cellulose. They do not contain any gelatin or other substances, so they are also very friendly to vegetarians or customers with special culture. In addition, they have a variety of color combinations to choose from, so you can customize different shells to distinguish different fillers.

Vegetarian Pill Capsules

Vegetarian Pill Capsules

Our Vegetarian Pill Capsules are made of high-quality carefully purchased plant nutrients, and all production processes comply with CGMP regulations, without any additives or sensitizing elements, and are suitable for the general public. They contain low water content, they will not be easily affected with damp or deteriorated during storage, and they can be decomposed within 15 minutes after eating, thus quickly volatilizing the drug effect. In addition, they are widely used in pharmaceutical industry, and can also be used as dietary supplements, which can wrap various fillers well and bring convenience for use.

Vegetable Capsules

Vegetable Capsules

Our Vegetable Capsules are empty capsules for filling solid particles and powders, which are made of high-quality plant ingredients, which can ensure that the contents are safely left inside and harmless to human body. They are very suitable for use in pharmacies, laboratories, hospitals and other occasions, because they have various color combinations and rulers to choose from to maintain the organization and classification of drugs. In addition, they are designed to be easy to open and can be filled and used anytime and anywhere to fully meet your daily vitamin and drug supply.

 

What is HPMC Empty Capsule

 

 

HPMC stands for hydroxypropyl methylcellulose or hypromellose for short. HPMC is the material from which most supplement capsules are made. It is a clear, tasteless, vegetarian and vegan appropriate material. It is normally made by extraction from wood pulp.

 

Benefits of HPMC Empty Capsule
 
1.Vegetarian and vegan-friendly

As mentioned earlier, HPMC capsules are a perfect alternative to gelatin capsules and are suitable for vegetarians and vegans. HPMC capsules are made from a plant-based polymer, which is derived from cellulose, making them ideal for individuals who follow a vegetarian or vegan lifestyle.

2.Easy to swallow

HPMC capsules are smooth and slippery, making them easy to swallow. They also have a lower risk of sticking in the throat or mouth than some other types of capsules. This feature is especially useful for individuals who have difficulty swallowing pills or capsules.

3.Non-toxic and safe

HPMC capsules are non-toxic and safe to use. The HPMC polymer used to make these capsules is biocompatible, which means it does not cause any adverse effects when it comes in contact with the human body. HPMC capsules are free from preservatives, allergens, and gluten, making them a safe choice for individuals with allergies or dietary restrictions.

4.Stable and resistant to moisture

HPMC capsules are stable and resistant to moisture, which makes them an ideal choice for encapsulating moisture-sensitive ingredients. HPMC capsules have a low moisture content, which reduces the risk of ingredient degradation or spoilage. This feature ensures that the ingredients remain potent and effective over a more extended period, maintaining the desired product quality.

5.Customizable

HPMC capsules can be customized to meet specific product requirements. The capsules come in various sizes, colors, and designs, enabling manufacturers to tailor the capsules to the specific needs of their products. Additionally, the capsules can be printed with logos or brand names, enhancing the product's appearance and increasing brand awareness.

6.Flexible and versatile

HPMC capsules are flexible and versatile, making them ideal for encapsulating both solids and liquids. The capsules can be used to encapsulate a wide range of ingredients, including vitamins, minerals, herbs, and pharmaceuticals. HPMC capsules are also suitable for encapsulating sensitive ingredients that may react with other encapsulation materials.

7.Environmentally friendly

HPMC capsules are environmentally friendly as they are made from renewable plant-based materials. They are also biodegradable, which means they can be broken down naturally without causing any harm to the environment. HPMC capsules provide an eco-friendly alternative to traditional gelatin capsules, which are derived from animal products and are not biodegradable.

 

HPMC Capsule Ingredients

 

 

This polymer is made with synthetic modification of the cellulose-based natural polymer. It is specifically a modification of alkali cellulose, which is created when the pure wood pulp is exposed to a solution of 18% sodium hydroxide. Alkali cellulose reacts with methyl chloride and propylene oxide, introducing methyl and hydroxypropyl ether groups into the molecule, respectively. Depending on the intended commercial use and desired properties, the degree of substitution (DS) of commercial HPMC with these methoxy and hydroxypropyl groups will change. These extra groups give the molecule its distinctive abilities to be soluble in cold water and to undergo reversible gelation when heated and cooled.

 

Speaking of HPMC capsule ingredients, the HPMC capsule is made of wood and is frequently referred to as natural. Of course, the capsules you purchase may or may not contain natural ingredients, but the shell itself will. Where the HPMC capsule has a color coating, the coating may be artificial. Titanium dioxide, a synthetic colorant that is frequently used to tint capsules, carries some health risks and is subject to precautions. Capsules can be naturally colored, but only in specific hues. Chlorophyll can be used to create different shades of green, and a purple carrot extract can be used to create a purple capsule shell.

 

HPMC capsules enable us to produce supplements devoid of additives. Glue, binders, fillers, and coating are necessary when producing tablets. The number of additional ingredients needed can be reduced by using HPMC capsules, which can contain only the active ingredient. HPMC welcomes vegetarians and vegans. Gelatin capsules have lost favor with savvy consumers because nobody really wants to ingest a capsule made of boiled cow bones if they have a choice. Although many capsules will have colors added, HPMC has no inherent flavor, aroma, or color. HPMC is typically simple to consume. Additionally, it breaks down in the stomach quite quickly, frequently in just 5–10 minutes. Bovine gelatin capsules require more than 20 minutes to dissolve. Using tablets can take hours.

 

HPMC Empty Capsule

 

Are HPMC Empty Capsule Natural?

The HPMC capsule itself is made from a wood source, so is often described as natural. Of course the contents of the capsules you buy may or may not be from a natural source, but the shell itself will be.

 

Where the HPMC capsule has been coated with a colour, the coating may well be synthetic. Titanium dioxide is commonly used to colour capsules, and this synthetic colourant has some associated health risks and warnings. It is possible to naturally colour capsules, but only in certain colours. Shades of green can be achieved with a coating of chlorophyll, and a purple capsule shell is available using a purple carrot extract.

 

 

How are HPMC Empty Capsules Produced?

The manufacturing process for HPMC capsules involves several steps, including blending the HPMC polymer with other ingredients to form a homogeneous mixture, encapsulating the mixture using a specialized machine, and then drying and polishing the capsules to achieve a smooth and uniform appearance. The final product is a clear, colorless, and odorless capsule that is suitable for use in a wide range of applications.

brown HPMC vegetable capsule shell

 

white Vegetarian empty capsule shells 0

 

How Long Does it Take to Dissolve HPMC Empty Capsules

The time it takes for HPMC capsules to dissolve can vary depending on various factors such as the size and composition of the capsule, the pH and temperature of the surrounding environment, and the nature of the contents within the capsule.

 

Generally speaking, HPMC capsules are designed to dissolve quickly in the presence of moisture, usually within a few minutes. However, the dissolution time can be affected by factors such as the viscosity and quantity of the liquid or powder contained within the capsule, the temperature and pH of the surrounding environment, and the presence of enzymes or other substances that may affect the rate of dissolution.

 

How to DIY Fill HPMC Empty Capsule

 

 

Uncap and push together method
1.Pour some of the powder you're planning to encapsulate onto either a small plate, or into a shallow bowl.
2.Take an empty capsule and uncap it so that the top is in one hand and the bottom is in the other.
3.With the center openings facing eachother, push them through the pile of powder and toward each other multiple times, until the large end (bottom half of capsule) is packed as full as possible.
4.If the top half of the capsule has too much powder in it, pour a little out so that they can be pushed together fully.
5.Push the capsule together.

 

Lab spoon or folded paper pour in method
1.Pour some of the powder you're planning to encapsulate onto either a small plate, or into a shallow bowl.
2.Take the bottom half of an empty capsule and hold it over the bowl with your powder
3.With the capsule opening face up in one hand, use the other hand to scoop powder with the lab spoon and pour it into the capsule opening. The excess will fall pack into the bowl of powder below it.

●If using a folded card or piece of paper, you can either put powder in the crevice of the fold first, and then pour it into the capsule, or use the folded card as a scooper and then pour it into the capsule. A business card folded long-ways works okay for this.
4.Once the bottom half of the capsule is full, you'll want to tamper the powder into it to make sure it's firmly packed.
●If your lab spoon didn't come with a tamper tool, then depending on the capsule size, you can use various cylindrical objects to do this. The the backside of a pen or pencil can work.
5.Once packed, add some more powder and repeat until the bottom half is fully and firmly packed.
6.Take the top half and press the capsule together until it clicks into place.

 

 
Certifications
 

 

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Our Factory
 

 

Prime Source Group is a top supplier in pharmaceutical industry and chemical industry. Empty Capsules, Aluminum Foil, PVC Sheet and Plastic Bottles are our main pharmaceutical related products. They are manufactured in three professional factories with rich experience and GMP workshops.

 

20220907131622247c8e3bcefd41b4aa992afd9483a035.jpg (900×634)

 

 
FAQ
 
 

Q: What are HPMC empty capsules?

A: HPMC empty capsules are made from hydroxypropyl methylcellulose (HPMC), a plant-based, biodegradable, and vegetarian alternative to gelatin capsules. They are used for encapsulating solid dosage forms like tablets, powders, granules, and small pellets.

Q: What is HPMC, and what are its properties?

A: HPMC is a cellulose derivative that is soluble in water. It has good film-forming properties, is non-toxic, and provides controlled release characteristics. HPMC is also resistant to heat and moisture, making it suitable for various pharmaceutical applications.

Q: How are HPMC capsules manufactured?

A: HPMC capsules are typically produced through a process known as extrusion-spheronization, where the HPMC material is mixed with water and other excipients, extruded into thin tubes, cut into segments, and then rounded into capsule shapes.

Q: What are the advantages of using HPMC capsules over gelatin capsules?

A: HPMC capsules offer several advantages, including being vegan, halal, and kosher-certified. They're also less likely to cause allergic reactions and can be used for products that require a gluten-free claim. HPMC is also stable across a wider range of pH levels and temperatures.

Q: Can HPMC capsules be used for enteric coating?

A: Yes, HPMC capsules can be enteric coated to protect the active ingredient from stomach acid and release it in the intestine. Enteric coatings are applied either on the inside or outside of the capsule shell.

Q: What factors should be considered when choosing HPMC capsule size?

A: The choice of HPMC capsule size depends on the volume and weight of the product to be encapsulated. A smaller size might be used for powder formulations, while larger sizes are suitable for tablets or pellets.

Q: How do HPMC capsules compare in terms of disintegration time?

A: HPMC capsules generally have longer disintegration times than gelatin capsules. The disintegration time can be adjusted by modifying the HPMC grade and cross-link density.

Q: What is the shelf life of HPMC empty capsules?

A: The shelf life of HPMC capsules is typically around two to three years when stored under proper conditions, away from heat, light, and humidity.

Q: Can HPMC capsules be used with moisture-sensitive drugs?

A: HPMC capsules have good moisture barrier properties, but they should still be used with caution for highly moisture-sensitive drugs. In such cases, additional measures, such as desiccants or moisture-proof packaging, may be necessary.

Q: How should HPMC capsules be handled during manufacturing and storage?

A: HPMC capsules should be handled with care to avoid damage and contamination. They should be stored in a cool, dry place, protected from light and air, and kept in their original packaging until use.

Q: What is the maximum load capacity of an HPMC capsule?

A: The maximum load capacity varies depending on the size and thickness of the HPMC capsule. Manufacturers typically provide guidelines based on the specific type of capsule.

Q: Can HPMC capsules be dissolved in water?

A: HPMC capsules are not designed to be dissolved in water. They are intended to remain intact until they reach the desired location in the gastrointestinal tract.

Q: What are the compatibility issues with HPMC capsules?

A: Some drugs or ingredients may be incompatible with HPMC. Compatibility testing is recommended before large-scale production to ensure there are no interactions that could affect the efficacy or safety of the drug.

Q: How do HPMC capsules perform in different pH environments?

A: HPMC capsules maintain their integrity across a wide range of pH levels, making them suitable for both acidic and alkaline environments within the gastrointestinal tract.

Q: Can HPMC capsules be used for time-release formulations?

A: Yes, HPMC capsules can be used for time-release formulations. Their controlled-release properties can be tailored by adjusting the HPMC grade and cross-link density.

Q: How do HPMC capsules compare in terms of cost?

A: HPMC capsules may be more expensive than gelatin capsules due to the higher cost of raw materials and production processes. However, the overall cost-effectiveness will depend on the specific application and required properties.

Q: Can HPMC capsules be customized?

A: Yes, HPMC capsules can be customized in terms of size, color, and imprinting to meet specific branding and identification requirements. Customization options may vary depending on the manufacturer.

Q: What is the effect of heat on HPMC capsules?

A: Exposure to high temperatures can cause HPMC capsules to lose their structural integrity and become sticky or misshapen. It is important to store and handle HPMC capsules at appropriate temperatures to maintain their quality.

Q: Can HPMC capsules be used for pediatric formulations?

A: HPMC capsules can be used for pediatric formulations, but the dosage form should be carefully designed to ensure ease of administration and compliance with pediatric use guidelines.

Q: How do HPMC capsules compare in terms of biodegradability?

A: HPMC is biodegradable and breaks down into water and carbon dioxide over time. However, the rate of biodegradation may vary depending on the specific conditions and environmental factors.

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